Novel IL-6 haplotypes and disease association
نویسندگان
چکیده
منابع مشابه
IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort.
It is unknown whether IL-6, a central regulator of inflammation, is a cause of or just a marker of atherosclerosis. Studies of genetic susceptibility to inflammation, however, avoid the potential for reverse causality. Variation in IL6 gene was studied as a predictor of cardiovascular disease (CVD) risk in a cohort of 775 incident dialysis patients, in whom IL-6 levels are elevated. On the basi...
متن کاملNegative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy
Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: In this cross-sectional casecontrol study, 212 subjects enrolled which were categorized in...
متن کاملAssociation of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease
Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protecti...
متن کاملIL-6 in inflammation, immunity, and disease.
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscriptional mechanisms, dysregulated continual synthesis of IL-6 plays a pathological effect on chron...
متن کاملnegative association of serum il-6 and il-17 with type-ii diabetes retinopathy
background: diabetes mellitus (dm) is a health concern which leads to complications such as retinopathy. pakistan has 6.9 million people living with dm and this toll will be doubled by 2025. objective: to determine serum il-6 and il-17 of type 2 diabetes mellitus (t2dm) patients with retinopathy. methods: in this cross-sectional casecontrol study, 212 subjects enrolled which were categorized in...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2005
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364186